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Chemical Structure : PF-07265807
CAS No.: 2412356-57-9
Catalog No.: PC-72618Not For Human Use, Lab Use Only.
PF-07265807 (PF 07265807) is a potent, selective dual Axl/Mer inhibitor with IC50 of 6.1 nM, 13.2 nM and 21.6 nM for AXL, MER and TYRO3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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PF-07265807 (PF 07265807) is a potent, selective dual Axl/Mer inhibitor with IC50 of 6.1 nM, 13.2 nM and 21.6 nM for AXL, MER and TYRO3, respectively.
PF-07265807 blocks Axl- and Mer-mediated signal transduction pathways, and inhibits proliferation and migration of Axl- and Mer-overexpressing tumor cells.
| M.Wt | 591.57 | |
| Formula | C29H27F2N7O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[3-Fluoro-4-[[3-[[(1R)-2-hydroxy-1-methylethyl]amino]-1H-pyrazolo[3,4-b]pyridin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-1,2,3,4-tetrahydro-1-(1-methylethyl)-2,4-dioxo-5-pyrimidinecarboxamide |
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1. Patent WO2020047184A1 (example 1).
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