Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Tyrosine Kinase-TAM Receptor (Tyro3-Axl-Mer)-PF-07265807
PF-07265807

Chemical Structure : PF-07265807

CAS No.: 2412356-57-9

Add to Favorites

PF-07265807 (PF 07265807)

Catalog No.: PC-72618Not For Human Use, Lab Use Only.

PF-07265807 (PF 07265807) is a potent, selective dual Axl/Mer inhibitor with IC50 of 6.1 nM, 13.2 nM and 21.6 nM for AXL, MER and TYRO3, respectively.

Packing Price Stock Quantity
10 mg $128 In stock
25 mg $218 In stock
50 mg $358 In stock
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PF-07265807 (PF 07265807) is a potent, selective dual Axl/Mer inhibitor with IC50 of 6.1 nM, 13.2 nM and 21.6 nM for AXL, MER and TYRO3, respectively.
PF-07265807 blocks Axl- and Mer-mediated signal transduction pathways, and inhibits proliferation and migration of Axl- and Mer-overexpressing tumor cells.

Physicochemical Properties

M.Wt 591.57
Formula C29H27F2N7O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[3-Fluoro-4-[[3-[[(1R)-2-hydroxy-1-methylethyl]amino]-1H-pyrazolo[3,4-b]pyridin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-1,2,3,4-tetrahydro-1-(1-methylethyl)-2,4-dioxo-5-pyrimidinecarboxamide

References

1. Patent WO2020047184A1 (example 1).

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: