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PF-184298

Chemical Structure : PF-184298

CAS No.: 813447-40-4

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PF-184298 (PF 184298)

Catalog No.: PC-61884Not For Human Use, Lab Use Only.

PF-184298 is a potent, selective dual serotonin and noradrenaline monoamine reuptake inhibitor (SNRI) with IC50 of 6 nM and 21 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-184298 is a potent, selective dual serotonin and noradrenaline monoamine reuptake inhibitor (SNRI) with IC50 of 6 nM and 21 nM, respectively.
    PF-184298 displays good selectivity over dopamine reuptake inhibition (DRI) (IC50=544 nM).
    PF-184298 possesses good in vitro metabolic stability, weak CYP inhibition and drug-like physicochemical properties consistent with CNS target space.

    Physicochemical Properties

    M.Wt 315.238
    Formula C15H20Cl2N2O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2,3-dichloro-N-isobutyl-N-pyrrolidin-3-ylbenzamide

    References

    1. Wakenhut F, et al. Bioorg Med Chem Lett. 2010 Jan 15;20(2):772.

    2. Harrison A, et al. Xenobiotica. 2012 Jan;42(1):57-74.

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