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PF-2545920 hydrochloride

Chemical Structure : PF-2545920 hydrochloride

CAS No.:

PF-2545920 hydrochloride (Mardepodect hydrochloride;MP-10 hydrochloride;PF-02545920 hydrochloride)

Catalog No.: PC-45822Not For Human Use, Lab Use Only.

A potent and selective PDE10A inhibitor with IC50 of 0.37 nM.

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50 mg $632 In stock

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A potent and selective PDE10A inhibitor with IC50 of 0.37 nM; displays >1,000-fold selectivity over the PDEs; antagonizes apomorphine-induced climbing in mice, inhibits conditioned avoidance responding in both rats and mice, and blocks NMDA antagonist-induced deficits in prepulse inhibition of acoustic startle response in rats; dose-dependently increases c-Fos immunopositive nuclei in all regions of neostriatum in the DRd1a-tdTomato mice; improves cortico-basal ganglia function in huntington's disease models; orally bioavailable.

Schizophrenia

Phase 2 Discontinued

Physicochemical Properties

M.Wt 428.9135
Formula C25H21ClN4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO

Chemical Name/SMILES

Quinoline, 2-[[4-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-,hydrochloride(1:1)

References

1. Verhoest PR, et al. J Med Chem. 2009 Aug 27;52(16):5188-96.

2. Grauer SM, et al. J Pharmacol Exp Ther. 2009 Nov;331(2):574-90.

3. Beaumont V, et al. Neuron. 2016 Dec 21;92(6):1220-1237.

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