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Chemical Structure : PF-3166
Catalog No.: PC-23180Not For Human Use, Lab Use Only.
PF-3166 is a potent, selective, noncovalent, cell-active peptidyl arginine deiminase 2 (PAD2) inhibitor with IC50 of 150 nM in fluorescence quenching (FQ) assay.
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PF-3166 is a potent, selective, noncovalent, cell-active peptidyl arginine deiminase 2 (PAD2) inhibitor with IC50 of 150 nM in fluorescence quenching (FQ) assay.
PF-3166 exhibits IC50 of 580 nM in NH3-release assay, with no inhibition of PAD3 or PAD4 activity.
PF-3166 selectively inhibits PAD2 with IC50 values of 610 nM (0.25 mM CaCl2) in GDH-coupled assay.
PF-3166 exhibits cellular activity with IC50 of 3 uM in ionomycin-stimulated human neutrophils.
| M.Wt | 870.26 | |
| Formula | C43H42BrClN6O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Byrnes LJ, et al. ACS Chem Biol. 2024 Sep 24. doi: 10.1021/acschembio.4c00397.
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