PF-3450074 |CAS:1352879-65-2 Probechem Biochemicals

Chemical Structure : PF-3450074

CAS No.: 1352879-65-2

PF-3450074 (PF3450074;PF-74;PF74)

Catalog No.: PC-63542Not For Human Use, Lab Use Only.

PF-3450074 (PF74) is a small molecule HIV capsid protein, destabilized the viral capsid in vitro.

Packing	Price	Stock
10 mg	$88	In stock
25 mg	$138	In stock
50 mg	$218	In stock
100 mg	$378	In stock
200 mg		Get quote
1 g		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

PF-3450074 (PF74) is a small molecule HIV capsid protein, destabilized the viral capsid in vitro.
PF-3450074 (PF74) acts at an early stage of HIV-1 infection and inhibits reverse transcription in target cells, induced the rapid dissolution of the HIV-1 capsid.
PF-3450074 (PF74) antiviral activity is promoted by binding of the host protein cyclophilin A to the HIV-1 capsid, and PF74 and cyclosporine exhibited mutual antagonism.

Physicochemical Properties

M.Wt	425.532
Formula	C27H27N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Methyl-N-[(1S)-2-(methylphenylamino)-2-oxo-1-(phenylmethyl)ethyl]- 1H-indole-3-acetamide

References

1. Shi J, et al. J Virol. 2011 Jan;85(1):542-9.

2. Shi J, et al. J Virol. 2015 Jan;89(1):208-19.

3. Zhou J, et al. J Virol. 2015 Sep;89(17):9068-79.

4. Saito A, et al. J Virol. 2016 May 27;90(12):5808-5823.

PF-3450074 (PF3450074;PF-74;PF74)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.