You are here:Home-Chemical Inhibitors & Agonists-Ras-Raf-MAPK-ERK Pathway-MAPKAPK2 (MK2)-PF-3644022
PF-3644022

Chemical Structure : PF-3644022

CAS No.: 1276121-88-0

PF-3644022 (PF 3644022;PF3644022)

Catalog No.: PC-70143Not For Human Use, Lab Use Only.

PF-3644022 is a potent and selective, freely reversible, ATP-competitive inhibitor of MAPKAP2 (MK2) with Ki of 3 nM.

Packing Price Stock Quantity
5 mg $248 In stock
10 mg $398 In stock
25 mg $588 In stock
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PF-3644022 is a potent and selective, freely reversible, ATP-competitive inhibitor of MAPKAP2 (MK2) with Ki of 3 nM.
PF-3644022 shows good selectivity against a panel of 200 human kinases.
PF-3644022 potently inhibits TNFα production with similar activity (IC50=160 nM) in U937 cells and hPBMCs, blocks TNFα and IL-6 production in LPS-stimulated human whole blood with IC50 of 1.6 and 10.3 uM, respectively.
PF-3644022 is activite in the rat LPS-induced TNFalpha model and orally efficacious.

Physicochemical Properties

M.Wt 374.46
Formula C21H18N4OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

100 mM in DMSO (37.4 mg/mL)

Chemical Name/SMILES

(10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one

References

1. Mourey RJ, et al. J Pharmacol Exp Ther. 2010 Jun;333(3):797-807.

2. Song H, et al. Am J Transl Res. 2015 Nov 15;7(11):2355-63.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: