PF-4181366 (PF-04181366) | PDE9A inhibitor

Chemical Structure : PF-4181366

PF-4181366 (PF-04181366, PF04181366, PF4181366)

Catalog No.: PC-60206Not For Human Use, Lab Use Only.

PF-4181366 (PF-04181366) is a potent, selective, brain penetrant PDE9A inhibitor with IC50 of 1.8 nM.

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Biological Activity

PF-4181366 (PF-04181366) is a potent, selective, brain penetrant PDE9A inhibitor with IC50 of 1.8 nM.
PF-4181366 (PF-04181366) displays >25-fold selectivity over other PDEs.

Physicochemical Properties

M.Wt	429.53
Formula	C24H27N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4H-Pyrazolo(3,4-d)pyrimidin-4-one, 1-cyclopentyl-1,5-dihydro-6-((3S,4S)-4-methyl-1-(6-quinoxalinylmethyl)-3-pyrrolidinyl)-

References

1. Verhoest PR, et al. J Med Chem. 2009 Dec 24;52(24):7946-9.

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PF-4181366 (PF-04181366, PF04181366, PF4181366)

Biological Activity

Physicochemical Properties

References

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