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PF-4181366

Chemical Structure : PF-4181366

CAS No.: 1082743-32-5

PF-4181366 (PF-04181366;PF04181366;PF4181366)

Catalog No.: PC-60206Not For Human Use, Lab Use Only.

A potent, selective, brain penetrant PDE9A inhibitor with IC50 of 1.8 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent, selective, brain penetrant PDE9A inhibitor with IC50 of 1.8 nM; displays >25-fold selectivity over other PDEs.

Physicochemical Properties

M.Wt 429.53
Formula C24H27N7O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4H-Pyrazolo(3,4-d)pyrimidin-4-one, 1-cyclopentyl-1,5-dihydro-6-((3S,4S)-4-methyl-1-(6-quinoxalinylmethyl)-3-pyrrolidinyl)-

References

1. Verhoest PR, et al. J Med Chem. 2009 Dec 24;52(24):7946-9.

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