PF-431396 | FAK/Pyk2 inhibitor | Probechem Biochemicals

Chemical Structure : PF-431396

CAS No.: 717906-29-1

Catalog No.: PC-62800Not For Human Use, Lab Use Only.

PF-431396 is a highly potent, dual PYK2/FAK inhibitor with IC50 of 11 and 2 nM, respectively, promotes osteogenesis of hMSC cultures.

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10 mg	$98	In stock
25 mg	$168	In stock
50 mg	$268	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PF-431396 is a highly potent, dual PYK2/FAK inhibitor with IC50 of 11 and 2 nM, respectively, promotes osteogenesis of hMSC cultures.

M.Wt	506.504
Formula	C22H21F3N6O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methylmethanesulfonamide

1. Han S, et al. J Biol Chem. 2009 May 8;284(19):13193-201.

2. Tse KW, et al. J Biol Chem. 2009 Aug 21;284(34):22865-77.

3. Mills RD, et al. J Biol Chem. 2015 Apr 3;290(14):8677-92.

4. Kanteti R, et al. Cancer Biol Ther. 2018 Jan 5:1-12.