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Chemical Structure : PF-46396
Catalog No.: PC-60408Not For Human Use, Lab Use Only.
PF-46396 is a specific small-molecule inhibitor of HIV-1 Gag maturation that interferes specifically with the cleavage of the CA/SP1 (p25) Gag precursor to the mature CA (p24) protein.
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PF-46396 is a specific small-molecule inhibitor of HIV-1 Gag maturation that interferes specifically with the cleavage of the CA/SP1 (p25) Gag precursor to the mature CA (p24) protein.
PF-46396 exhibits antiviral activity against 17/27 HIV-1 clinical isolates with EC50s ranging from 0.005 to 7 uM and TI values ranging from 2 to 3,400.
| M.Wt | 454.537 | |
| Formula | C27H29F3N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Blair WS, et al. Antimicrob Agents Chemother. 2009 Dec;53(12):5080-7.
2. Murgatroyd C, et al. J Virol. 2016 Aug 26;90(18):8181-97.
3. Waki K, et al. PLoS Pathog. 2012;8(11):e1002997.
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