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PF-4693627

Chemical Structure : PF-4693627

CAS No.: 1312815-93-2

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PF-4693627 (PF 4693627)

Catalog No.: PC-20721Not For Human Use, Lab Use Only.

PF-4693627 is a potent, selective and orally bioavailable mPGES-1 inhibitor with IC50 of 3 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-4693627 is a potent, selective and orally bioavailable mPGES-1 inhibitor with IC50 of 3 nM.
    PF-4693627 exhibits an IC50 of 109 nM in LPS-stimulated human whole blood (HWB) cell assays, and IC50 of 6 nM in a fetal fibroblast cell assay.
    PF-4693627 displays high selectivity over relevant human enzymes TXAS, PGDS, 5-LOX, 15-LOX and 12-LOX.
    PF-4693627 (10 mg/kg, oral) is effective in a carrageenan-stimulated guinea pig air pouch model of inflammation.

    Physicochemical Properties

    M.Wt 502.44
    Formula C26H29Cl2N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(5-chloro-6-(4-chlorophenyl)benzo[d]oxazol-2-yl)-N-((1S,3S)-3-(hydroxymethyl)cyclohexyl)piperidine-4-carboxamide

    References

    1. Arhancet GB, et al. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1114-9.

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