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Chemical Structure : PF-4778574
Catalog No.: PC-35556Not For Human Use, Lab Use Only.
PF-4778574 (PF4778574) is a brain penetrant, positive allosteric modulator (potentiator) of AMPA receptor with Ki of 85 nM, increases S-AMPA-evoked responses in rat primary cortical neurons with EC50 of 45-919 nM.
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PF-4778574 (PF4778574) is a brain penetrant, positive allosteric modulator (potentiator) of AMPA receptor with Ki of 85 nM, increases S-AMPA-evoked responses in rat primary cortical neurons with EC50 of 45-919 nM.
PF-4778574 robustly ameliorates ketamine-induced working memory impairments in vivo.
| M.Wt | 390.516 | |
| Formula | C19H22N2O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shaffer CL, et al. J Pharmacol Exp Ther. 2013 Oct;347(1):212-24.
2. Roberts BM, et al. Behav Brain Res. 2010 Sep 1;212(1):41-8.
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