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PF-4778574

Chemical Structure : PF-4778574

CAS No.: 1219633-99-4

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PF-4778574 (PF4778574;PF 4778574)

Catalog No.: PC-35556Not For Human Use, Lab Use Only.

PF-4778574 (PF4778574) is a brain penetrant, positive allosteric modulator (potentiator) of AMPA receptor with Ki of 85 nM, increases S-AMPA-evoked responses in rat primary cortical neurons with EC50 of 45-919 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-4778574 (PF4778574) is a brain penetrant, positive allosteric modulator (potentiator) of AMPA receptor with Ki of 85 nM, increases S-AMPA-evoked responses in rat primary cortical neurons with EC50 of 45-919 nM.
    PF-4778574 robustly ameliorates ketamine-induced working memory impairments in vivo.

    Physicochemical Properties

    M.Wt 390.516
    Formula C19H22N2O3S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-{(3R,4S)-3-[4-(5-cyano-2-thienyl)phenyl]tetrahydro-2H-pyran-4-yl}propane-2-sulfonamide

    References

    1. Shaffer CL, et al. J Pharmacol Exp Ther. 2013 Oct;347(1):212-24.

    2. Roberts BM, et al. Behav Brain Res. 2010 Sep 1;212(1):41-8.

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