Chemical Structure : PF-4800567
CAS No.:
1188296-52-7
PF-4800567
(PF4800567)
Catalog No. : PC-24728Not For Human Use, Lab Use Only.
PF-4800567 is a potent, selective inhibitor of casein kinase 1 epsilon (CK1epsilon, CK1ε) with IC50 of 32 nM, >20-fold selectivity over CK1δ.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-2472801
Biological Activity
PF-4800567 is a potent, selective inhibitor of casein kinase 1 epsilon (CK1epsilon, CK1ε) with IC50 of 32 nM, >20-fold selectivity over CK1δ.
Physicochemical Properties
M.Wt
359.81
Formula
C17H18ClN5O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
3-((3-Chlorophenoxy)methyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
References
1. Walton KM, et al. J Pharmacol Exp Ther. 2009 Aug;330(2):430-9.
2. Meng QJ, et al. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15240-5.
3. Bryant CD, et al. Neuropsychopharmacology. 2012 Mar;37(4):1026-35.
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