Catalog No.: PC-60681Not For Human Use, Lab Use Only.
PF-4950834 is a potent, selective, ATP-competitive and orally acitve Rho kinase (ROCK) inhibitor with IC50 of 33.1 and 8.5 nM for ROCK1 and ROCK2, respectively.
PF-4950834 is a potent, selective, ATP-competitive and orally acitve Rho kinase (ROCK) inhibitor with IC50 of 33.1 and 8.5 nM for ROCK1 and ROCK2, respectively.
PF-4950834 displays 5-140-fold selectivity over other AGC kinase family.
PF-4950834 inhibits Jurkat T cell migration with IC50 of 68.4 nM, suppresses activation of both LPA- and thrombin-mediated activation of Rho kinase, and blocked both LPA-induced and thrombin-induced expression of ICAM-1 and VCAM-1 in HUVECs.
PF-4950834 attenuates leukocyte migration in vivo.
