Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : PF-5006739
CAS No.: 1293395-67-1
Catalog No.: PC-61114Not For Human Use, Lab Use Only.
PF-5006739 is a potent, selective casein kinase CK1δ/ε inhibitor with IC50 of 3.9/17.0 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
PF-5006739 is a potent, selective casein kinase CK1δ/ε inhibitor with IC50 of 3.9/17.0 nM, respectively.
PF-5006739 demonstrates excellent kinome selectivity in a 59-kinase panel with exception of JNK2 (IC50=6.1 uM) and ZC3 (IC50=1.5 uM).
PF-5006739 exhibits robust centrally mediated circadian rhythm phase-delaying effects in both nocturnal and diurnal animal models, attenuates opioid drug-seeking behavior in a rodent operant reinstatement model in animals trained to self-administer fentanyl.
PF-5006739 also improves glucose tolerance in both DIO and genetic (ob/ob) models of obesity.
| M.Wt | 419.464 | |
| Formula | C22H22FN7O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-{4-(4-Fluorophenyl)-1-[1-(1,2-oxazol-3-ylmethyl)piperidin-4-yl]-1H-imidazol-5-yl}pyrimidin-2-amine |
|
1. Wager TT, et al. ACS Chem Neurosci. 2014 Dec 17;5(12):1253-65.
2. Cunningham PS, et al. Sci Rep. 2016 Jul 21;6:29983.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
