Chemical Structure : PF-5081090
CAS No.: 1312473-63-4
Catalog No.: PC-26543Not For Human Use, Lab Use Only.
PF-5081090 (LpxC-4) is a highly potent LpxC inhibitor with IC50 of 1.1 nM (P. aeruginosa LpxC) and MIC90 of 1 ug/mL, inhibits lipid A biosynthesis and is synergistic with azithromycin, rifampin, or vancomycin for multidrug-resistant A. baumannii.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $328 | In stock | |
| 25 mg | $548 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PF-5081090 (LpxC-4) is a highly potent LpxC inhibitor with IC50 of 1.1 nM (P. aeruginosa LpxC) and MIC90 of 1 ug/mL, inhibits lipid A biosynthesis and is synergistic with azithromycin, rifampin, or vancomycin for multidrug-resistant A. baumannii.
| M.Wt | 412.43 | |
| Formula | C18H21FN2O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-4-(4-(2-Fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide |
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1. García-Quintanilla M, et al. Antimicrob Agents Chemother. 2016 Jul 22;60(8):5076-9.
2. Niu Z, et al. Eur J Med Chem. 2023 May 5;253:115326.

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