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Chemical Structure : PF-562271 besylate
CAS No.: 939791-38-5
Catalog No.: PC-42600Not For Human Use, Lab Use Only.
A potent, selective, ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase with IC50 of 1.5 nM and 14 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PF-562271 besylate is a potent, selective, ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase with IC50 of 1.5 nM and 14 nM, respectively.
PF-562271 displayes robust inhibition in an inducible cell-based assay measuring phospho-FAK with IC50 of 5 nM.
PF-562271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion (EC50=93 ng/mL) after in tumor-bearing mice; orally bioavailable.
| M.Wt | 665.6639 | |
| Formula | C27H26F3N7O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 21.4 mg/mL |
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| Chemical Name/SMILES |
Methanesulfonamide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methyl-, benzenesulfonate (1:1) |
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1. Roberts WG, et al. Cancer Res. 2008 Mar 15;68(6):1935-44.
2. Stokes JB, et al. Mol Cancer Ther. 2011 Nov;10(11):2135-45.
3. Slack-Davis JK, et al. Mol Cancer Ther. 2009 Aug;8(8):2470-7.
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