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Chemical Structure : PF-573228
CAS No.: 869288-64-2
Catalog No.: PC-42602Not For Human Use, Lab Use Only.
PF-573228 is a potent, selective, ATP-competitive FAK inhibitor with IC50 of 4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $18 | In stock | |
| 10 mg | $98 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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PF-573228 is a potent, selective, ATP-competitive FAK inhibitor with IC50 of 4 nM.
PF-573228 displays 250-fold selectivity over Pyk2, 50–250-fold over a panel of kinases (CDK1, CDK7, GSK3β).
PF-573228 inhibits FAK phosphorylation on Tyr397 in cultured cells (IC50=30-100 nM), inhibits both chemotactic and haptotactic migration.
| M.Wt | 491.4861 | |
| Formula | C22H20F3N5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 51 mg/mL |
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| Chemical Name/SMILES |
2(1H)-Quinolinone, 3,4-dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]- |
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1. Slack-Davis JK, et al. J Biol Chem. 2007 May 18;282(20):14845-52.
2. Jones ML, et al. Biochem Biophys Res Commun. 2009 Nov 6;389(1):198-203.
3. Hiscox S, et al. Breast Cancer Res Treat. 2011 Feb;125(3):659-69.
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