Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Tyrosine Kinase-Breast Tumor Kinase (BRK;PTK6)-PF-6683324
PF-6683324

Chemical Structure : PF-6683324

CAS No.: 1799788-94-5

Add to Favorites

PF-6683324 (PF6683324)

Catalog No.: PC-35187Not For Human Use, Lab Use Only.

PF-6683324 (PF6683324) is a potent and selective Type II PTK6/Brk inhibitor with IC50 of 76 nM in biochemical assays.

Packing Price Stock Quantity
5 mg Get quote
10 mg Get quote
25 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-6683324 (PF6683324) is a potent and selective Type II PTK6/Brk inhibitor with IC50 of 76 nM in biochemical assay.
    PF-6683324 inhibits PTK6 phosphorylation at Y342 in engineered HET293T cells overexpressing PTK6 WT with IC50 of 0.7 uM。
    PF-6683324 demonstrates superior kinase selectivity compared to the Type I inhibitors.

    Physicochemical Properties

    M.Wt 521.473
    Formula C24H23F4N5O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(((3S,4R)-3-fluoro-1-(2-(4-(trifluoromethoxy)phenyl)acetyl)piperidin-4-yl)oxy)-5-(1-methyl-1H-imidazol-4-yl)nicotinamide

    References

    1. Qiu L, et al. PLoS One. 2018 Jun 7;13(6):e0198374.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: