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Chemical Structure : PF-6683324
Catalog No.: PC-35187Not For Human Use, Lab Use Only.
PF-6683324 (PF6683324) is a potent and selective Type II PTK6/Brk inhibitor with IC50 of 76 nM in biochemical assays.
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PF-6683324 (PF6683324) is a potent and selective Type II PTK6/Brk inhibitor with IC50 of 76 nM in biochemical assay.
PF-6683324 inhibits PTK6 phosphorylation at Y342 in engineered HET293T cells overexpressing PTK6 WT with IC50 of 0.7 uM。
PF-6683324 demonstrates superior kinase selectivity compared to the Type I inhibitors.
| M.Wt | 521.473 | |
| Formula | C24H23F4N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Qiu L, et al. PLoS One. 2018 Jun 7;13(6):e0198374.
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