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PF-794

Chemical Structure : PF-794

CAS No.: 2375197-49-0

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PF-794 (PF 794, PF794)

Catalog No.: PC-60644Not For Human Use, Lab Use Only.

PF-794 (PF794) is a potent, specific and ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with IC50 of 39 nM in cell-free assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-794 (PF794) is a potent, specific and ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with IC50 of 39 nM in cell-free assays.
    PF-794 displays excellent kinome selectivity with exception of MINK1 and MAP4K4 (>60% inhibition at 1 uM).
    PF-794 significantly inhibits TNIK-induced phosphorylation of p120-catenin, reduces pT312-immunoprecipitated p120-catenin in neurons.

    Physicochemical Properties

    M.Wt 356.429
    Formula C22H20N4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(6-amino-5-(4-cyanophenyl)pyridin-3-yl)-N-isopropylbenzamide

    References

    1. Wang Q, et al. J Pharmacol Exp Ther. 2016 Feb;356(2):410-23.

    2. Guimarães CR, et al. J Chem Inf Model. 2011 Jun 27;51(6):1199-204.

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