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Chemical Structure : PF-794
Catalog No.: PC-60644Not For Human Use, Lab Use Only.
PF-794 (PF794) is a potent, specific and ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with IC50 of 39 nM in cell-free assays.
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PF-794 (PF794) is a potent, specific and ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with IC50 of 39 nM in cell-free assays.
PF-794 displays excellent kinome selectivity with exception of MINK1 and MAP4K4 (>60% inhibition at 1 uM).
PF-794 significantly inhibits TNIK-induced phosphorylation of p120-catenin, reduces pT312-immunoprecipitated p120-catenin in neurons.
| M.Wt | 356.429 | |
| Formula | C22H20N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang Q, et al. J Pharmacol Exp Ther. 2016 Feb;356(2):410-23.
2. Guimarães CR, et al. J Chem Inf Model. 2011 Jun 27;51(6):1199-204.
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