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PF-9184

Chemical Structure : PF-9184

CAS No.: 1221971-47-6

PF-9184 (PF9184)

Catalog No.: PC-61665Not For Human Use, Lab Use Only.

PF-9184 is a potent, selective mPGES-1 (microsomal prostaglandin E synthase-1) inhibitor with IC50 of 16.5 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PF-9184 is a potent, selective mPGES-1 (microsomal prostaglandin E synthase-1) inhibitor with IC50 of 16.5 nM.
PF-9184 shows no effect against COX-1 and COX-2 (>6,500-fold selectivity).
PF-9184 inhibits PGE2 synthesis in serum-free cell and human whole blood cultures with IC50 of 0.5-5 uM, while sparing the synthesis of PGF(1alpha)) and PGF(2alpha).

Physicochemical Properties

M.Wt 461.3
Formula C21H14Cl2N2O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2H-1,2-Benzothiazine-3-carboxamide, N-(3',4'-dichloro[1,1'-biphenyl]-4-yl)-4-hydroxy-,1,1-dioxide

References

1. Mbalaviele G, et al. Biochem Pharmacol. 2010 May 15;79(10):1445-54.

2. Chang HH, et al. Future Med Chem. 2011 Nov;3(15):1909-34.

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