Chemical Structure : PF-9184
CAS No.: 1221971-47-6
Catalog No.: PC-61665Not For Human Use, Lab Use Only.
PF-9184 is a potent, selective mPGES-1 (microsomal prostaglandin E synthase-1) inhibitor with IC50 of 16.5 nM.
Packing | Price | Stock | Quantity |
---|---|---|---|
5 mg | $158 | In stock | |
10 mg | $248 | In stock | |
25 mg | $428 | In stock | |
50 mg | $728 | In stock | |
100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
PF-9184 is a potent, selective mPGES-1 (microsomal prostaglandin E synthase-1) inhibitor with IC50 of 16.5 nM.
PF-9184 shows no effect against COX-1 and COX-2 (>6,500-fold selectivity).
PF-9184 inhibits PGE2 synthesis in serum-free cell and human whole blood cultures with IC50 of 0.5-5 uM, while sparing the synthesis of PGF(1alpha)) and PGF(2alpha).
M.Wt | 461.3 | |
Formula | C21H14Cl2N2O4S | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
|
Chemical Name/SMILES |
2H-1,2-Benzothiazine-3-carboxamide, N-(3',4'-dichloro[1,1'-biphenyl]-4-yl)-4-hydroxy-,1,1-dioxide |
1. Mbalaviele G, et al. Biochem Pharmacol. 2010 May 15;79(10):1445-54.
2. Chang HH, et al. Future Med Chem. 2011 Nov;3(15):1909-34.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright