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Chemical Structure : PF-9184
CAS No.: 1221971-47-6
Catalog No.: PC-61665Not For Human Use, Lab Use Only.
PF-9184 is a potent, selective mPGES-1 (microsomal prostaglandin E synthase-1) inhibitor with IC50 of 16.5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $428 | In stock | |
| 50 mg | $728 | In stock | |
| 100 mg | Get quote |
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PF-9184 is a potent, selective mPGES-1 (microsomal prostaglandin E synthase-1) inhibitor with IC50 of 16.5 nM.
PF-9184 shows no effect against COX-1 and COX-2 (>6,500-fold selectivity).
PF-9184 inhibits PGE2 synthesis in serum-free cell and human whole blood cultures with IC50 of 0.5-5 uM, while sparing the synthesis of PGF(1alpha)) and PGF(2alpha).
| M.Wt | 461.3 | |
| Formula | C21H14Cl2N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2H-1,2-Benzothiazine-3-carboxamide, N-(3',4'-dichloro[1,1'-biphenyl]-4-yl)-4-hydroxy-,1,1-dioxide |
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1. Mbalaviele G, et al. Biochem Pharmacol. 2010 May 15;79(10):1445-54.
2. Chang HH, et al. Future Med Chem. 2011 Nov;3(15):1909-34.
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