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Chemical Structure : PF-9363
CAS No.: 2569009-58-9
Catalog No.: PC-72392Not For Human Use, Lab Use Only.
PF-9363 (CTx-648) is a first-in-class, potent and selective KAT6A/6B inhibitor with Ki of 0.41 nM and 1.2 nM for KAT6A and KAT6B, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | $558 | In stock | |
| 100 mg | Get quote |
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PF-9363 (CTx-648) is a first-in-class, potent and selective KAT6A/6B inhibitor with Ki of 0.41 nM and 1.2 nM for KAT6A and KAT6B, respectively.
PF-9363 (CTx-648) possess high selectivity versus other MYST family members (KAT7, KAT5, KAT8).
PF-9363 (CTx-648) inhibits expression of ESR1 expression leading to potent anti-tumor activity in ER+ breast cancer models.
PF-9363 (CTx-648) displays potent anti-tumor activity in ER+ breast cancer models.
| M.Wt | 444.462 | |
| Formula | C20H20N4O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(6-((1H-pyrazol-1-yl)methyl)-4-methoxybenzo[d]isoxazol-3-yl)-2,6-dimethoxybenzenesulfonamide |
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1. Shikhar Sharma, et al. Cancer Res (2021) 81 (13_Supplement): 1130.
2. Shikhar Sharma, et al. Cell Chem Biol. 2023 Aug 8;S2451-9456(23)00234-9.
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