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PF-9363

Chemical Structure : PF-9363

CAS No.: 2569009-58-9

PF-9363 (CTx-648, PF9363, CTx648)

Catalog No.: PC-72392Not For Human Use, Lab Use Only.

PF-9363 (CTx-648) is a first-in-class, potent and selective KAT6A/6B inhibitor with Ki of 0.41 nM and 1.2 nM for KAT6A and KAT6B, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PF-9363 (CTx-648) is a first-in-class, potent and selective KAT6A/6B inhibitor with Ki of 0.41 nM and 1.2 nM for KAT6A and KAT6B, respectively.
PF-9363 (CTx-648) possess high selectivity versus other MYST family members (KAT7, KAT5, KAT8).
PF-9363 (CTx-648) inhibits expression of ESR1 expression leading to potent anti-tumor activity in ER+ breast cancer models.
PF-9363 (CTx-648) displays potent anti-tumor activity in ER+ breast cancer models.

Physicochemical Properties

M.Wt 444.462
Formula C20H20N4O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(6-((1H-pyrazol-1-yl)methyl)-4-methoxybenzo[d]isoxazol-3-yl)-2,6-dimethoxybenzenesulfonamide

References

1. Shikhar Sharma, et al. Cancer Res (2021) 81 (13_Supplement): 1130.
2. Shikhar Sharma, et al. Cell Chem Biol. 2023 Aug 8;S2451-9456(23)00234-9.

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