Chemical Structure : PF 05180999
CAS No.:
1394033-54-5
PF 05180999
(PF-05180999;PF05180999;PF 5180999)
Catalog No. : PC-60564Not For Human Use, Lab Use Only.
PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6056401
Biological Activity
PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A ) inhibitor with IC50 of 1 nM.
Physicochemical Properties
M.Wt
414.396
Formula
C19H17F3N8
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4-(1-Azetidinyl)-7-methyl-5-[1-methyl-5-[5-(trifluoromethyl)-2-pyridinyl]-1H-pyrazol-4-yl]-imidazo[5,1-f][1,2,4]triazine
References
1. Mikami S, et al. J Med Chem
2. Helal CJ, et al. J Med Chem
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