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PF 05180999

Chemical Structure : PF 05180999

CAS No.: 1394033-54-5

PF 05180999 (PF-05180999;PF05180999;PF 5180999)

Catalog No.: PC-60564Not For Human Use, Lab Use Only.

PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM.
PF-05180999 displays >1,000-fold selectivity over PDE10.
PF-05180999 shows potential for treatment of schizophrenia.

Physicochemical Properties

M.Wt 414.396
Formula C19H17F3N8
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(1-Azetidinyl)-7-methyl-5-[1-methyl-5-[5-(trifluoromethyl)-2-pyridinyl]-1H-pyrazol-4-yl]-imidazo[5,1-f][1,2,4]triazine

References

1. Mikami S, et al. J Med Chem. 2017 Sep 28;60(18):7677-7702.

2. Helal CJ, et al. J Med Chem. 2018 Jan 2. doi: 10.1021/acs.jmedchem.7b01466.

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