Chemical Structure : PF670462 dihydrochloride
CAS No.: 950912-80-8
Catalog No.: PC-23901Not For Human Use, Lab Use Only.
PF-670462 dihydrochloride (PF670462) is a potent and selective inhibitor casein kinase CK1ε and CK1δ with IC50 of 7.7 nM and 14 nM, respectively.
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PF-670462 dihydrochloride (PF670462) is a potent and selective inhibitor casein kinase CK1ε and CK1δ with IC50 of 7.7 nM and 14 nM, respectively.
PF-670462 causes a significant phase delay in animal models of circadian rhythm.
| M.Wt | 410.32 | |
| Formula | C19H22Cl2FN5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-(1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl)pyrimidin-2-amine dihydrochloride |
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1. Badura L, et al. J Pharmacol Exp Ther. 2007 Aug;322(2):730-8.
2. Bryant CD, et al. Psychopharmacology (Berl). 2009 May;203(4):703-11.
3. Walton KM, et al. J Pharmacol Exp Ther. 2009 Aug;330(2):430-9.

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