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PGC-1α inhibitor C80

Chemical Structure : PGC-1α inhibitor C80

CAS No.: 154191-98-7

PGC-1α inhibitor C80

Catalog No.: PC-62697Not For Human Use, Lab Use Only.

PGC-1α inhibitor C80 is a potent PGC-1α inhibitor, activates PGC-1α acetylation with AC50 of 3.1 uM, induces Pck1 and G6pc expression with AC50 of 11.9 uM and 12.8 uM, reduces glucose production in hepatocytes.

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    Biological Activity

    PGC-1α inhibitor C80 is a potent PGC-1α inhibitor, activates PGC-1α acetylation with AC50 of 3.1 uM, induces Pck1 and G6pc expression with AC50 of 11.9 uM and 12.8 uM, reduces glucose production in hepatocytes.

    Physicochemical Properties

    M.Wt 380.532
    Formula C24H32N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    1-(tert-butyl(4-methylbenzyl)amino)-3-((3-methyl-1H-indol-4-yl)oxy)propan-2-ol

    References

    1. Sharabi K, et al. Cell. 2017 Mar 23;169(1):148-160.e15.

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