PGC-1α inhibitor C80

Chemical Structure : PGC-1α inhibitor C80

Catalog No.: PC-62697Not For Human Use, Lab Use Only.

PGC-1α inhibitor C80 is a potent PGC-1α inhibitor, activates PGC-1α acetylation with AC50 of 3.1 uM, induces Pck1 and G6pc expression with AC50 of 11.9 uM and 12.8 uM, reduces glucose production in hepatocytes.

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Biological Activity

PGC-1α inhibitor C80 is a potent PGC-1α inhibitor, activates PGC-1α acetylation with AC50 of 3.1 uM, induces Pck1 and G6pc expression with AC50 of 11.9 uM and 12.8 uM, reduces glucose production in hepatocytes.

Physicochemical Properties

M.Wt	380.532
Formula	C24H32N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(tert-butyl(4-methylbenzyl)amino)-3-((3-methyl-1H-indol-4-yl)oxy)propan-2-ol

References

1. Sharabi K, et al. Cell. 2017 Mar 23;169(1):148-160.e15.

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