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Chemical Structure : PGN-9856
CAS No.: 863704-91-0
Catalog No.: PC-35836Not For Human Use, Lab Use Only.
PGN-9856 (PGN9856) is a novel potent, selective prostaglandin EP2 receptor agonist with pKi of > 8.3, shows high selectivity over EP1 , EP3 , EP4 , DP, FP, IP and TP receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $488 | In stock | |
| 50 mg | $788 | In stock | |
| 100 mg | Get quote |
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PGN-9856 (PGN9856) is a novel potent, selective prostaglandin EP2 receptor agonist with pKi of > 8.3, shows high selectivity over EP1 , EP3 , EP4 , DP, FP, IP and TP receptors.
PGN-9856 displays a potency (pEC50 >8.5) and a maximal response (increase in cAMP) comparable to that of the endogenous agonist PGE2 in cells over-expressing human recombinant EP2 receptors.
PGN-9856 exhibited tocolytic, anti-inflammatory, and long-acting ocular hypotensive properties consistent with its potent EP2 agonist properties.
| M.Wt | 383.351 | |
| Formula | C21H15F2NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(3-(3',4-difluoro-[1,1'-biphenyl]-3-carboxamido)phenoxy)acetic acid |
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1. Coleman RA, et al. Br J Pharmacol. 2018 Oct 20. doi: 10.1111/bph.14525.
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