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PGN 9856-isopropyl ester

Chemical Structure : PGN 9856-isopropyl ester

CAS No.: 1177429-82-1

PGN 9856-isopropyl ester (PGN-9856 isopropyl ester)

Catalog No.: PC-35836ANot For Human Use, Lab Use Only.

PGN 9856-isopropyl ester is the isopropyl ester, which is a potent, selective prostaglandin EP2 receptor agonist with pKi of > 8.3.

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Purity & Documentation Purity: 98.65% (HPLC) Select Batch:

Biological Activity

PGN 9856-isopropyl ester is the isopropyl ester, which is a potent, selective prostaglandin EP2 receptor agonist with pKi of > 8.3.
PGN 9856-isopropyl ester produced profound decreases in monkey intraocular pressure (IOP).
PGN 9856-isopropyl ester appears to possess efficacy and duration of action properties unmatched by currently prescribed anti-glaucoma agents.

Physicochemical Properties

M.Wt 425.43
Formula C24H21F2NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

isopropyl 2-(3-(3',4-difluoro-[1,1'-biphenyl]-3-carboxamido)phenoxy)acetate

References

1. Woodward DF, et al. J Ocul Pharmacol Ther. 2019 Jun;35(5):265-277.

2. Coleman RA, et al. Br J Pharmacol. 2019 Mar;176(5):687-698.

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