Catalog No.: PC-22783Not For Human Use, Lab Use Only.
PHA-543613 is a potent, selective agonist of alpha7 neuronal nicotinic acetylcholine receptor (α7 nAChR) with Ki of 8.8 nM, EC50 of 65 nM in cell-based FLIPR assay.
PHA-543613 is a potent, selective agonist of alpha7 neuronal nicotinic acetylcholine receptor (α7 nAChR) with Ki of 8.8 nM, EC50 of 65 nM in cell-based FLIPR assay. PHA-543613 shows no detectible agonist activity (>100 μM) and negligible antagonist activity at both muscle-like nAChRs (TE671 cells) and ganglion-like nAChRs (SH-SY5Y cells), as well as α4β2 nAChR subtype. PHA-543613 is characterized by rapid brain penetration and high oral bioavailability in rat and demonstrates in vivo efficacy in auditory sensory gating and, in an in vivo model to assess cognitive performance, novel object recognition.
