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PHI-101

Chemical Structure : PHI-101

CAS No.: 2127107-15-5

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PHI-101 (Lasmotinib, PHI101)

Catalog No.: PC-24145Not For Human Use, Lab Use Only.

Lasmotinib (PHI-101) is a potent, selectivean orally bioavailable next-generation FLT3 inhibitor, potently inhibits FLT3 single activating mutations (ITD or TKD mutants) and has inhibitory activity against FLT3 double (ITD/D835Y or ITD/F691L) and triple (ITD/D835Y/F691L) resistance mutations.

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5 mg $118 In stock
10 mg $188 In stock
25 mg $328 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Lasmotinib (PHI-101) is a potent, selectivean orally bioavailable next-generation FLT3 inhibitor, potently inhibits FLT3 single activating mutations (ITD or TKD mutants) and has inhibitory activity against FLT3 double (ITD/D835Y or ITD/F691L) and triple (ITD/D835Y/F691L) resistance mutations.

Physicochemical Properties

M.Wt 386.45
Formula C19H19FN4O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-5-((3-fluorophenyl)ethynyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide

References

1. Park SJ, et al. BMC Cancer. 2022 Jan 3;22(1):28.

2. Sung-Soo Yoon, et al. Blood (2023) 142 (Supplement 1): 4283.

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