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PHY34

Chemical Structure : PHY34

CAS No.: 2130033-55-3

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PHY34

Catalog No.: PC-35620Not For Human Use, Lab Use Only.

PHY34 is a potent autophagy inhibitor with cytotoxic effects by inhibiting autophagy at a late stage (MDA-MB-435 IC50=23 nM, MDA-MB-231 IC50=5.2 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PHY34 is a potent autophagy inhibitor with cytotoxic effects by inhibiting autophagy at a late stage (MDA-MB-435 IC50=23 nM, MDA-MB-231 IC50=5.2 nM).
    PHY34 disrupts lysosomal function, significantly inhibits the growth of cancer cell lines in hollow fibers, as well as reduces ovarian tumor burden in a xenograft model.

    Physicochemical Properties

    M.Wt 522.506
    Formula C28H26O10
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    9-(benzo[d][1,3]dioxol-5-yl)-4-(((3aS,4R,6S,7R,7aR)-7-hydroxy-4-(hydroxymethyl)-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-6-yl)oxy)naphtho[2,3-c]furan-1(3H)-one

    References

    1. Young AN, et al. Mol Cancer Ther. 2018 Jul 17. pii: molcanther.1195.2017.

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