PI3Kα-IN-4h |CAS:2100855-80-7 Probechem Biochemicals

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Chemical Structure : PI3Kα-IN-4h

PI3Kα-IN-4h

Catalog No.: PC-62843Not For Human Use, Lab Use Only.

PI3Kα-IN-4h is a potent, selective, ATP-competitive dual PI3Kα/mTOR inhibitor with IC50 of 0.5/104 nM respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PI3Kα-IN-4h is a potent, selective, ATP-competitive dual PI3Kα/mTOR inhibitor with IC50 of 0.5/104 nM respectively.
PI3Kα-IN-4h displays good selectivity for PI3Kα.
PI3Kα-IN-4h demonstrates cytotoxicity in MCF7 cells, reasonable toxicity in MDA-MB-468 cells, good therapeutic index compared to normal skin fibroblasts, and acceptable in vitro ADME properties.

Physicochemical Properties

M.Wt	483.532
Formula	C26H25N7O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(3-(4-(4-morpholinopyrido[3,2-d]pyrimidin-2-yl)phenyl)ureido)phenyl)acetamide

References

1. Al-Ashmawy AAK, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3117-3122.

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PI3Kα-IN-4h

Biological Activity

Physicochemical Properties

References

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