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Chemical Structure : PIPE-3297
Catalog No.: PC-21712Not For Human Use, Lab Use Only.
PIPE-3297 is a fully efficacious and selective kappa opioid receptor (KOR) agonist with functional GTPγS EC50 of 1.1 nM, Emax=91%, does not elicit β-arrestin-2 recruitment functional response.
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PIPE-3297 is a fully efficacious and selective kappa opioid receptor (KOR) agonist with functional GTPγS EC50 of 1.1 nM, Emax=91%, does not elicit β-arrestin-2 recruitment functional response.
PIPE-3297 displays 40- and 600-fold selectivity for the KOR over the related MOR and delta opioid receptor (DOR) respectively.
PIPE-3297 effectively induced oligodendrocyte progenitor cells (OPCs) differentiation of isolated rat OPCs, reaching 90% of T3-control differentiation.
PIPE-3297 (3 and 30 mg/kg, s.c.) reduced the disease score in the mouse experimental autoimmune encephalomyelitis (EAE) model.
| M.Wt | 350.51 | |
| Formula | C23H30N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Thomas O Schrader, et al. ACS Chem Neurosci. 2024 Jan 24. doi: 10.1021/acschemneuro.3c00807.
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