Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-GPCR-mAChR-PIPE-359
PIPE-359

Chemical Structure : PIPE-359

CAS No.: 2401785-66-6

Add to Favorites

PIPE-359 (PIPE359)

Catalog No.: PC-20509Not For Human Use, Lab Use Only.

PIPE-359 (PIPE359) is a potent, selective and brain-penetrant antagonist of muscarinic acetylcholine receptor subtype 1 (M1 mAChR) with IC50 of 1.8 nM and Ki of 0.14 nM (hM1R).

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
200 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PIPE-359 (PIPE359) is a potent, selective and brain-penetrant antagonist of muscarinic acetylcholine receptor subtype 1 (M1 mAChR) with IC50 of 1.8 nM and Ki of 0.14 nM (hM1R).
    PIPE-359 exhibited good-to-excellent selectivities versus the hM2R, hM3R, and hM4R in both functional and binding settings.
    PIPE-359 (30 mg/kg po qd) exhibited robust efficacy in mouse myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalitis (EAE), a preclinical model for multiple sclerosis.

    Physicochemical Properties

    M.Wt 467.56
    Formula C22H21N5O3S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N#CC1=CN=C(N2C3CN(C(CCS(=O)(C4=C(SC=N5)C5=CC=C4)=O)=O)CC2CC3)C=C1

    References

    1. Thomas O Schrader, et al. ACS Med Chem Lett. 2020 Dec 24;12(1):155-161.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: