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PK-THPP

Chemical Structure : PK-THPP

CAS No.: 1332454-07-5

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PK-THPP

Catalog No.: PC-20698Not For Human Use, Lab Use Only.

TASK-3 inhibitor 23 is a potent, selective inhibitor of TWIK-related acid-sensitive K+ (K2P9.1, TASK-3) ion channel with IC50 of 30 nM, 10-fold selectivity over TASK-1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PK-THPP is a potent, selective inhibitor of TWIK-related acid-sensitive K+ (K2P9.1, TASK-3) ion channel with IC50 of 30 nM, 10-fold selectivity over TASK-1.
PK-THPP demonstrated pharmacological target engagement as indicated by its ability to modulate sleep architecture in rodent electroencephalogram (EEG) telemetry models.

Physicochemical Properties

M.Wt 468.60
Formula C29H32N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(1-(6-([1,1'-biphenyl]-4-carbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)piperidin-4-yl)butan-1-one

References

1. Craig A Coburn, et al. ChemMedChem. 2012 Jan 2;7(1):123-33.

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