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Chemical Structure : PK-THPP
Catalog No.: PC-20698Not For Human Use, Lab Use Only.
TASK-3 inhibitor 23 is a potent, selective inhibitor of TWIK-related acid-sensitive K+ (K2P9.1, TASK-3) ion channel with IC50 of 30 nM, 10-fold selectivity over TASK-1.
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PK-THPP is a potent, selective inhibitor of TWIK-related acid-sensitive K+ (K2P9.1, TASK-3) ion channel with IC50 of 30 nM, 10-fold selectivity over TASK-1.
PK-THPP demonstrated pharmacological target engagement as indicated by its ability to modulate sleep architecture in rodent electroencephalogram (EEG) telemetry models.
| M.Wt | 468.60 | |
| Formula | C29H32N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Craig A Coburn, et al. ChemMedChem. 2012 Jan 2;7(1):123-33.
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