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PKUMDL-WQ-2201

Chemical Structure : PKUMDL-WQ-2201

CAS No.: 592474-91-4

PKUMDL-WQ-2201 (WQ-2201)

Catalog No.: PC-72880Not For Human Use, Lab Use Only.

PKUMDL-WQ-2201 is a potent, selective, allosteric inhibitor of PHGDH, binds to allosteric site II.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PKUMDL-WQ-2201 is a potent, selective, allosteric inhibitor of PHGDH, binds to allosteric site II.
PKUMDL-WQ-2201 inhibited the serine biosynthesis pathway in cells, exhibited substantial inhibitory effects on MDA-MB-468 xenografts.

Physicochemical Properties

M.Wt 351.805
Formula C15H14ClN3O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-Chloro-4-[5-[(ethylcarbamothioylhydrazinylidene)methyl]furan-2-yl]benzoic acid

References

1. Qian Wang, et al. Cell Chem Biol. 2017 Jan 19;24(1):55-65.

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