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Chemical Structure : PKZ18-22
Catalog No.: PC-38554Not For Human Use, Lab Use Only.
PKZ18-22 is a potency improved analog of PKZ18, inhibitiong tRNA-regulated gene expression of gram-positive bacteria, shows MIC value of 8 ug/mL against S. aureus.
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PKZ18-22 is a potency improved analog of PKZ18, inhibitiong tRNA-regulated gene expression of gram-positive bacteria, shows MIC value of 8 ug/mL against S. aureus.
PKZ18-22 inhibited T-box-controlled expression of glyQS in the glycine auxotroph B. subtilis 1A5, with increasing concentrations showing increased termination of read-through by reverse transcription-quantitative PCR (qRT-PCR).
PKZ18-22 showed no cytotoxicity against eukaryotic cells and significantly lowered the effective dose of gentamicin.
| M.Wt | 398.521 | |
| Formula | C22H26N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Väre VYP, et al. Antimicrob Agents Chemother. 2020 Dec 16;65(1):e01247-20.
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