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Chemical Structure : PKZ18
CAS No.: 849658-87-3
Catalog No.: PC-38553Not For Human Use, Lab Use Only.
PKZ18 is a small-molecule antibiotic inhibiting the in vivo transcription of glycyl-tRNA synthetase mRNA in gram-positive bacteria, aslo inhibits in vivo translation of the S. aureus threonyl-tRNA synthetase protein.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $388 | In stock | |
| 25 mg | $588 | In stock | |
| 100 mg | Get quote |
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PKZ18 is a small-molecule antibiotic inhibiting the in vivo transcription of glycyl-tRNA synthetase mRNA in gram-positive bacteria, aslo inhibits in vivo translation of the S. aureus threonyl-tRNA synthetase protein.
PKZ8 has MIC value of 32 to 64 μg/ml against most Gram-positive bacteria.
PKZ18 bound to the the GlyQS specifier Loop in vitro with Kd of 24 uM.
PKZ18 targets the site of the codon-anticodon interaction of the conserved stem I and reduces T-box-controlled gene expression.
| M.Wt | 398.521 | |
| Formula | C22H26N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1s,2r,3s,4r)-3-((4-(4-Isopropylphenyl)-5-methylthiazol-2-yl)carbamoyl)bicyclo[2.2.1]heptane-2-carboxylic acid |
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1. Frohlich KM, et al. ChemMedChem. 2019 Apr 3;14(7):758-769.
2. Väre VYP, et al. Antimicrob Agents Chemother. 2020 Dec 16;65(1):e01247-20.
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