PLK1 inhibitor B31

Chemical Structure : PLK1 inhibitor B31

Catalog No.: PC-24019Not For Human Use, Lab Use Only.

PLK1 inhibitor B31 is a potent, highly selective and orally active inhibitor of polo-like kinase 1 (PLK1) with IC50 of 20 nM, >200-fold selective over PLK2/PLK3.

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Biological Activity

PLK1 inhibitor B31 is a potent, highly selective and orally active inhibitor of polo-like kinase 1 (PLK1) with IC50 of 20 nM, >200-fold selective over PLK2/PLK3.

Physicochemical Properties

M.Wt	558.12
Formula	C28H40ClN7O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-((3-Chloro-2-(3-hydroxypropoxy)-5-(4-methylpiperazin-1-yl)phenyl)amino)-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one

References

1. Nie J, et al. J Med Chem. 2025 Feb 18. doi: 10.1021/acs.jmedchem.4c02422.

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