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PMD-026

Chemical Structure : PMD-026

CAS No.:

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PMD-026 (PMD026)

Catalog No.: PC-72284Not For Human Use, Lab Use Only.

PMD-026 (PMD026) is an oral, reversible small molecule inhibitor of ribosomal S6 kinases (RSK1-4) with IC50 of 2 nM (RSK1), 0.7 nM (RSK2), 0.9 nM (RSK3) and 2 nM (RSK4).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PMD-026 (PMD026) is an oral, reversible small molecule inhibitor of ribosomal S6 kinases (RSK1-4) with IC50 of 2 nM (RSK1), 0.7 nM (RSK2), 0.9 nM (RSK3) and 2 nM (RSK4).
PMD-026 decreased YB-1 phosphorylation as well as AR V7 mRNA and AR variants expressions in 22Rv1 cells.
PMD-026 suppressed cell proliferation alone and in combination with the second-generation antiandrogens enzalutamide and darolutamide by inducing cellular apoptosis and G2/M arrest.
PMD-026 suppressed tumor growth, and the combination of PMD-026 and enzalutamide inhibited tumor growth more prominently than single treatment in mouse xenograft models.

Physicochemical Properties

M.Wt
Formula
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

Chemical Name/SMILES

References

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