Catalog No.: PC-42901Not For Human Use, Lab Use Only.
PNU-120596 (NSC 216666) is a potent, selective α7 nAChR positive allosteric modulator (PAM) that enhances ACh-evoked Ca2+ flux with EC50 of 216 nM, displays no activity for α3β4, α4β2 and α9β10 nAChRs.
PNU-120596 (NSC 216666) is a potent, selective α7 nAChR positive allosteric modulator (PAM) that enhances ACh-evoked Ca2+ flux with EC50 of 216 nM, displays no activity for α3β4, α4β2 and α9β10 nAChRs.
PNU-120596 increases the channel mean open time of α7 nAChRs but has no effect on ion selectivity and little to no effect on unitary conductance.
PNU-120596 increases the frequency of ACh-evoked GABAergic postsynaptic currents in pyramidal neurons.
PNU-120596 improves the auditory gating deficit caused by amphetamine, a model of schizophrenia.
