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Chemical Structure : POMHEX
CAS No.: 2004714-34-3
Catalog No.: PC-38629Not For Human Use, Lab Use Only.
POMHEX is a cell-permeable, small-molecule ENO2-specific enolase inhibitor, exhibits selective killing against ENO1-deleted glioma cells with IC50 of 30 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $378 | In stock | |
| 10 mg | $558 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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POMHEX is a cell-permeable, small-molecule ENO2-specific enolase inhibitor, exhibits selective killing against ENO1-deleted glioma cells with IC50 of 30 nM.
POMHEX displays weak acitivty against non-target ENO1-WT cells (IC50>1.5 uM).
POMHEX selectively induces energy stress, inhibits proliferation, and triggers apoptosis in ENO1-deleted glioma cells.
POMHEX eradicates intracranial orthotopic ENO1-deleted tumors in mice at doses well-tolerated in non-human primates.
| M.Wt | 423.40 | |
| Formula | C17H30NO9P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1,1′-[[(1-Hydroxy-2-oxo-3-piperidinyl)phosphinylidene]bis(oxymethylene)] bis(2,2-dimethylpropanoate) |
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1. Sunada Khadka, et al. Cancer Metab. 2021 Jun 25;9(1):27.
2. Yu-Hsi Lin, et al. Nat Metab. 2020 Dec;2(12):1413-1426.
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