PP121 |CAS:1092788-83-4 Probechem Biochemicals

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Chemical Structure : PP121

CAS No.: 1092788-83-4

PP121 (PP 121;PP-121)

Catalog No.: PC-42555Not For Human Use, Lab Use Only.

A multitargeted, dual tyrosine and PI3K kinase inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2, 8, 10, 12, 14 and 18 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PP121 is a multitargeted, dual tyrosine and PI3K kinase inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2, 8, 10, 12, 14 and 18 nM.
PP121 also inhibits Ret, VEGFR-2, 110α/mTOR, potently inhibits both tyrosine kinases and PI3Ks but not serine-threonine kinases.

Physicochemical Properties

M.Wt	319.3638
Formula	C17H17N7
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-

References

1. Apsel B, et al. Nat Chem Biol. 2008 Nov;4(11):691-9.

2. Che HY, et al. Tumour Biol. 2014 Sep;35(9):8659-64.

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PP121 (PP 121;PP-121)

Biological Activity

Physicochemical Properties

References

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