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PPBI

Chemical Structure : PPBI

CAS No.: 959863-95-7

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PPBI (M1 agonist PPBI)

Catalog No.: PC-61789Not For Human Use, Lab Use Only.

PPBI is a potent, selective, full M1 muscarinic agonist with EC50 of 5, 8, and 21 nM for human, rat, and mouse M1 receptors, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PPBI is a potent, selective, full M1 muscarinic agonist with EC50 of 5, 8, and 21 nM for human, rat, and mouse M1 receptors, respectively.
    PPBI displays a functional potency more than 10-fold than that of M4, >100-fold more potent over M2, M3 and M5.
    PPBI reverses d-amphetamine locomotor activity, also reverses a natural deficit in a rat cognition model.
    PPBI is analgesic in a variety of rat and mouse models.

    Physicochemical Properties

    M.Wt 376.432
    Formula C19H25FN4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ethyl (S)-3-(4-(6-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)pyrrolidine-1-carboxylate

    References

    1. Wood MW, et al. Neuropharmacology. 2017 Sep 1;123:233-241.

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