Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : PPI-2458
Catalog No.: PC-63319Not For Human Use, Lab Use Only.
PPI-2458 is potent, specific, irreversible methionine aminopeptidase-2 (MetAP-2) inhibitor with IC50 of 0.2 nM, inhibits growth inhibition of HFLS-RA and HUVEC with IC50 of 0.04 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
PPI-2458 is potent, specific, irreversible methionine aminopeptidase-2 (MetAP-2) inhibitor with IC50 of 0.2 nM, inhibits growth inhibition of HFLS-RA and HUVEC with IC50 of 0.04 nM.
PPI-2458 significantly attenuates paw swelling when therapeutically administered after the onset of chronic disease in rat model of peptidoglycan-polysaccharide-induced arthritis.
PPI-2458 exhibits potent antiproliferative activity on NHL lines in vitro (GI50=0.2-1.9 nM) and oral antitumor activity in vivo.
| M.Wt | 424.53 | |
| Formula | C22H36N2O6 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Bernier SG, et al. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10768-73.
2. Hannig G, et al. Int J Oncol. 2006 Apr;28(4):955-63.
3. Cooper AC, et al. Clin Cancer Res. 2006 Apr 15;12(8):2583-90.
4. Hannig G, et al. Arthritis Rheum. 2007 Mar;56(3):850-60.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
