Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-PQ-10
PQ-10

Chemical Structure : PQ-10

CAS No.: 927691-21-2

Add to Favorites

PQ-10 (PDE10A inhibitor PQ10, PQ10)

Catalog No.: PC-61348Not For Human Use, Lab Use Only.

PQ-10 is a potent, selective, brain penetrant PDE10A inhibitor with Ki of 4 nM.

Packing Price Stock Quantity
10 mg $98 In stock
25 mg $168 In stock
50 mg $268 In stock
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PQ-10 is a potent, selective, brain penetrant PDE10A inhibitor with Ki of 4 nM.
PQ-10 displays 53-fold and 68-fold selectivity over PDE3A and PDE3B, respectively.
PQ-10 selectively inhibits colon tumor cell growth with IC50 of 0.1-28 uM.
PQ-10 selectively activates cGMP/cGMP-dependent protein kinase signaling to suppress β-catenin levels and T-cell factor (TCF) transcriptional activity in colon tumor cells.

Physicochemical Properties

M.Wt 403.442
Formula C22H21N5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline

References

1. Li N, et al. Oncogene. 2015 Mar 19;34(12):1499-509.

2. Chappie TA, et al. J Med Chem. 2007 Jan 25;50(2):182-5.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: