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Chemical Structure : PQ-10
CAS No.: 927691-21-2
Catalog No.: PC-61348Not For Human Use, Lab Use Only.
PQ-10 is a potent, selective, brain penetrant PDE10A inhibitor with Ki of 4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $168 | In stock | |
| 50 mg | $268 | In stock | |
| 100 mg | Get quote |
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PQ-10 is a potent, selective, brain penetrant PDE10A inhibitor with Ki of 4 nM.
PQ-10 displays 53-fold and 68-fold selectivity over PDE3A and PDE3B, respectively.
PQ-10 selectively inhibits colon tumor cell growth with IC50 of 0.1-28 uM.
PQ-10 selectively activates cGMP/cGMP-dependent protein kinase signaling to suppress β-catenin levels and T-cell factor (TCF) transcriptional activity in colon tumor cells.
| M.Wt | 403.442 | |
| Formula | C22H21N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline |
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1. Li N, et al. Oncogene. 2015 Mar 19;34(12):1499-509.
2. Chappie TA, et al. J Med Chem. 2007 Jan 25;50(2):182-5.
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