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PQ-10

Chemical Structure : PQ-10

CAS No.: 927691-21-2

PQ-10 (PDE10A inhibitor PQ10;PQ10)

Catalog No.: PC-61348Not For Human Use, Lab Use Only.

A potent, selective, brain penetrant PDE10A inhibitor with Ki of 4 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent, selective, brain penetrant PDE10A inhibitor with Ki of 4 nM; displays 53-fold and 68-fold selectivity over PDE3A and PDE3B, respectively; selectively inhibits colon tumor cell growth with IC50 of 0.1-28 uM; selectively activates cGMP/cGMP-dependent protein kinase signaling to suppress β-catenin levels and T-cell factor (TCF) transcriptional activity in colon tumor cells.

Physicochemical Properties

M.Wt 403.442
Formula C22H21N5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline

References

1. Li N, et al. Oncogene. 2015 Mar 19;34(12):1499-509.

2. Chappie TA, et al. J Med Chem. 2007 Jan 25;50(2):182-5.

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