PQC 083 | NGF inhibitor | Probechem Biochemicals

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Chemical Structure : PQC 083

PQC 083 (PQC083, PQC-083)

Catalog No.: PC-62757Not For Human Use, Lab Use Only.

PQC 083 is a novel nerve growth factor (NGF) antagonist with IC50 of 7.0 uM, functionally inhibits NGF's effects on PC12 cell differentiation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PQC 083 is a novel nerve growth factor (NGF) antagonist with IC50 of 7.0 uM, functionally inhibits NGF's effects on PC12 cell differentiation.
PQC 083 is a useful biochemical tool for studying NGF-dependent effects in biochemical or cell biology systems.

Physicochemical Properties

M.Wt	318.249
Formula	C12H10N6O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5,7-diamino-4-methyl-3-nitro-9-oxo-4,9-dihydropyrazolo[5,1-b]quinazoline-2-carboxylic acid

References

1. Eibl JK, et al. Eur J Pharmacol. 2013 May 15;708(1-3):30-7.

2. Sheffield KS, et al. Pharmacol Res. 2016 Jan;103:292-9.

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PQC 083 (PQC083, PQC-083)

Biological Activity

Physicochemical Properties

References

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