PR-104A | DNA alkylating agent | Probechem Biochemicals

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Chemical Structure : PR-104A

PR-104A (SN27858)

Catalog No.: PC-23373Not For Human Use, Lab Use Only.

PR-104A is a hypoxia-selective DNA cross-linking agent/DNA-damaging agent and cytotoxin, alcohol metabolite of phosphate proagent PR-104, which shows selective DNA cross-linking selective cytotoxicity under hypoxia in cancer cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	499.29
Formula	C14H19BrN4O9S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2-Bromoethyl)(2-((2-hydroxyethyl)carbamoyl)-4,6-dinitrophenyl)amino)ethyl methanesulfonate

References

1. Moradi Manesh D, et al. Blood. 2015 Sep 3;126(10):1193-202.

2. McKeage MJ, et al. BMC Cancer. 2012 Oct 25;12:496.

3. Adam V Patterson, et al. Clin Cancer Res. 2007 Jul 1;13(13):3922-32.

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PR-104A (SN27858)

Biological Activity

Physicochemical Properties

References

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