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PRE-084 hydrochloride

Chemical Structure : PRE-084 hydrochloride

CAS No.: 75136-54-8

PRE-084 hydrochloride (PRE084 hydrochloride)

Catalog No.: PC-45419Not For Human Use, Lab Use Only.

PRE-084 is a highly potent, selective sigma-1 receptor agonist with Ki of 2.2 nM, IC50 of 44 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PRE-084 hydrochloride is a highly potent, selective sigma-1 receptor agonist with Ki of 2.2 nM, IC50 of 44 nM.
PRE-084 shows little or no affinity for sigma-2 and PCP receptors (Ki>10 uM).
PRE-084 has nootropic and antidepressant actions in vivo, as well as antitussive and reinforcing effects.

Physicochemical Properties

M.Wt 353.8835
Formula C19H28ClNO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 34 mg/mL

Chemical Name/SMILES

Cyclohexanecarboxylic acid, 1-phenyl-, 2-(4-morpholinyl)ethyl ester, hydrochloride (1:1)

References

1. Su TP, et al. J Pharmacol Exp Ther. 1991 Nov;259(2):543-50.

2. Brown C, et al. Br J Pharmacol. 2004 Jan;141(2):233-40.

3. Maurice T, et al. Br J Pharmacol. 2001 Dec;134(8):1731-41.

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