Chemical Structure : PRE-084 hydrochloride
CAS No.: 75136-54-8
Catalog No.: PC-45419Not For Human Use, Lab Use Only.
PRE-084 is a highly potent, selective sigma-1 receptor agonist with Ki of 2.2 nM, IC50 of 44 nM.
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PRE-084 hydrochloride is a highly potent, selective sigma-1 receptor agonist with Ki of 2.2 nM, IC50 of 44 nM.
PRE-084 shows little or no affinity for sigma-2 and PCP receptors (Ki>10 uM).
PRE-084 has nootropic and antidepressant actions in vivo, as well as antitussive and reinforcing effects.
M.Wt | 353.8835 | |
Formula | C19H28ClNO3 | |
Appearance | Solid | |
Storage |
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Solubility |
DMSO: ≥ 34 mg/mL |
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Chemical Name/SMILES |
Cyclohexanecarboxylic acid, 1-phenyl-, 2-(4-morpholinyl)ethyl ester, hydrochloride (1:1) |
1. Su TP, et al. J Pharmacol Exp Ther. 1991 Nov;259(2):543-50.
2. Brown C, et al. Br J Pharmacol. 2004 Jan;141(2):233-40.
3. Maurice T, et al. Br J Pharmacol. 2001 Dec;134(8):1731-41.
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