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PRN473

Chemical Structure : PRN473

CAS No.: 1581714-49-9

PRN473 (Atuzabrutinib, SAR 444727, PRN-473)

Catalog No.: PC-38012Not For Human Use, Lab Use Only.

PRN473 (Atuzabrutinib, SAR 444727, PRN-473) is a potent, selective, covalent reversible BTK inhibitor.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PRN473 (Atuzabrutinib, SAR 444727, PRN-473) is a potent, selective, covalent reversible BTK inhibitor.
PRN473 demonstrates in vivo efficacy in rodent arthritis models, and clinical efficacy in canine pemphigus foliaceus. PRN473 has completed phase 1 trials as a topical agent.

Physicochemical Properties

M.Wt 539.615
Formula C30H30FN7O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R,E)-2-(3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4,4-dimethylpent-2-enenitrile

References

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