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Chemical Structure : PROTAC dCE-1
Catalog No.: PC-21708Not For Human Use, Lab Use Only.
PROTAC dCE-1 is a potent, selective CBP/EP300 degrader targeting the histone acetyltransferase (HAT) domain, with DC50 value of 1.3 μM in LP1 cells.
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PROTAC dCE-1 is a potent, selective CBP/EP300 degrader targeting the histone acetyltransferase (HAT) domain, with DC50 value of 1.3 μM in LP1 cells.
dCE-1 induces foci formation in the FluoPPI assay with an EC50 of 1.2 μM.
dCE-1 has antiproliferative effects in a panel of cell lines through the NCI-60 screen.
dCE-1 is consisting of the HAT inhibitor CPI-1612 conjugated via a 24-atom linker to pomalidomide.
| M.Wt | 1071.20 | |
| Formula | C56H66N10O12 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Iván Cheng-Sánchez, et al. ACS Medicinal Chemistry Letters, January 26, 2024
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