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PROTAC dCE-1

Chemical Structure : PROTAC dCE-1

CAS No.:

PROTAC dCE-1

Catalog No.: PC-21708Not For Human Use, Lab Use Only.

PROTAC dCE-1 is a potent, selective CBP/EP300 degrader targeting the histone acetyltransferase (HAT) domain, with DC50 value of 1.3 μM in LP1 cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PROTAC dCE-1 is a potent, selective CBP/EP300 degrader targeting the histone acetyltransferase (HAT) domain, with DC50 value of 1.3 μM in LP1 cells.
dCE-1 induces foci formation in the FluoPPI assay with an EC50 of 1.2 μM.
dCE-1 has antiproliferative effects in a panel of cell lines through the NCI-60 screen.
dCE-1 is consisting of the HAT inhibitor CPI-1612 conjugated via a 24-atom linker to pomalidomide.

Physicochemical Properties

M.Wt 1071.20
Formula C56H66N10O12
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(4-(6-((R)-2-(((S)-2-(4-cyanophenyl)propyl)amino)-2-phenylacetamido)pyridin-3-yl)-1H-pyrazol-1-yl)-N-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-2,5,8,11,14,17-hexaoxanonadecan-19-yl)butanamide

References

1. Iván Cheng-Sánchez, et al. ACS Medicinal Chemistry Letters, January 26, 2024

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